Integrated manufacturing of REciclable multi-material COmposites for the TRANSport sector
A Superparamagnetic Composite Hydrogel Scaffold as In Vivo Dynamic Monitorable Theranostic Platform for Osteoarthritis Regeneration
A theranostic material, composite hydrogel scaffold (CHS), is synthesized based on glycidyl methacrylate modified hyaluronic acid (GMHA) and hollow porous magnetic hydroxyapatite?Fe3O4 microspheres. The vascular endothelial growth factor (VEGF)?loaded CHS exhibits subchondral bone repair function and achieves high cartilage repair scores. Its process can dynamically monitor using MRI. The CHS provides a versatile platform for osteoarthritis (OA) treatment.Osteoarthritis (OA) is a prevalent disease, characterized by subchondral fractures in its initial stages, which has no precise and specific treatment now. Here, a novel multifunctional scaffold is synthesized by photopolymerizing glycidyl methacrylate?modified hyaluronic acid (GMHA) as the matrix in the presence of hollow porous magnetic microspheres based on hydroxyapatite. In vivo subchondral bone repairing results demonstrate that the scaffold's meticulous design has most suitable properties for subchondral bone repair. The porous structure of inorganic particles within the scaffold facilitates efficient transport of loaded exogenous vascular endothelial growth factor (VEGF). The Fe3O4 nanoparticles assembled in microspheres promote the osteogenic differentiation of bone marrow mesenchymal stem cells and accelerate the new bone generation. These features enable the scaffold to exhibit favorable subchondral bone repair properties and attain high cartilage repair scores. The therapy results prove that the subchondral bone support considerably influences the upper cartilage repair process. Furthermore, magnetic resonance imaging monitoring demonstrates that Fe3O4 nanoparticles, which are gradually replaced by new bone during osteochondral defect repair, allow a noninvasive and radiation?free assessment to track the newborn bone during the OA repair process. The composite hydrogel scaffold (CHS) provides a versatile platform for biomedical applications in OA treatment.
» Publication Date: 06/07/2024
This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement Nº 768737
