Integrated manufacturing of REciclable multi-material COmposites for the TRANSport sector
A Nanozyme?Based Electrode for High?Performance Neural Recording
Neural electrodes are indispensable diagnostic and therapeutic tools for neurological disorders. However, their detection sensitivity and biocompatibility remain unsolved challenges. Here, nanozyme electrodes that can simultaneously overcome the limitations associated with recording sensitivity, long?term acquisition stability, and peripheral nerve tissue necrosis through interfacial quantum transport and inhibition of neuroinflammation are developed, which are promising for brain science and engineering.Implanted neural electrodes have been widely used to treat brain diseases that require high sensitivity and biocompatibility at the tissue–electrode interface. However, currently used clinical electrodes cannot meet both these requirements simultaneously, which hinders the effective recording of electronic signals. Herein, nanozyme?based neural electrodes incorporating bioinspired atomically precise clusters are developed as a general strategy with a heterogeneous design for multiscale and ultrasensitive neural recording via quantum transport and biocatalytic processes. Owing to the dual high?speed electronic and ionic currents at the electrode–tissue interface, the impedance of nanozyme electrodes is 26 times lower than that of state?of?the?art metal electrodes, and the acquisition sensitivity for the local field potential is ?10 times higher than that of clinical PtIr electrodes, enabling a signal?to?noise ratio (SNR) of up to 14.7 dB for single?neuron recordings in rats. The electrodes provide more than 100?fold higher antioxidant and multi?enzyme?like activities, which effectively decrease 67% of the neuronal injury area by inhibiting glial proliferation and allowing sensitive and stable neural recording. Moreover, nanozyme electrodes can considerably improve the SNR of seizures in acute epileptic rats and are expected to achieve precise localization of seizure foci in clinical settings.
» Publication Date: 07/12/2023
This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement Nº 768737
