Integrated manufacturing of REciclable multi-material COmposites for the TRANSport sector
NANOCRYSTALS, COMPOSITIONS, AND METHODS THAT AID PARTICLE TRANSPORT IN MUCUS
Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.
» Number: US2017266120A1 (A1)
» Publication Date: 21/09/2017
» Applicant: UNIV JOHNS HOPKINS?[US]
» Inventor: POPOV ALEXEY?[US]; ENLOW ELIZABETH M?[US] (8)
This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement Nº 768737
